US Knee Replacement Market by Type, Application, Technology, Distribution Channel, and Organization Size: 2020-2035
The US knee replacement market is experiencing rapid advancement, driven by technological innovation, rising prevalence of degenerative joint conditions, and growing demand for improved mobility among aging populations. With developments such as robotic-assisted surgery and 3D-printed implants, the market outlook remains robust through 2035. Key industry players are advancing new product lines and investing in minimally invasive techniques, while healthcare systems strive to keep pace with evolving patient needs and regulatory requirements.
Latest Market Dynamics
Key Drivers
Increasing prevalence of osteoarthritis and an aging population is driving up the number of knee replacement procedures. Companies like Zimmer Biomet are expanding their product portfolios in response to heightened demand for knee implants tailored to an older population base.
Technological innovations, including robotic-assisted knee replacement and 3D-printing of implants, have significantly improved surgical outcomes and patient satisfaction. Stryker Corporation has recently expanded its MAKO robotic system offerings, enhancing the adoption rate of precision-based surgery in major US hospitals.
Key Trends
The rise of outpatient knee replacement procedures in ambulatory surgical centers is accelerating market growth. Smith & Nephew’s NAVIO Surgical System supports this trend by enabling minimally invasive approaches with shorter recovery times.
The shift toward gender-specific and patient-customized implants, such as those invented by Conformis, is gaining traction as patients and surgeons seek better anatomical fit and performance.
Key Opportunities
The adoption of artificial intelligence and machine learning in preoperative planning opens new avenues for personalized patient care and optimized implant positioning, as seen with Johnson & Johnson’s recent AI-driven software development.
Expansion into underserved geographic and demographic segments promises revenue growth. Companies like MicroPort Scientific are making strategic investments to improve knee replacement access in rural and underserved US regions.
Key Challenges
High procedure costs and limited insurance reimbursement can restrict patient access, especially in non-urban areas. Medtronic is developing value-based care solutions to address affordability and reimbursement concerns.
Regulatory and compliance hurdles can impede the speedy introduction of novel implants or techniques, exemplified by delays experienced by Exactech in launching its new high-flexion knee system.
Key Restraints
Potential for post-surgical infections and prosthetic failures continues to limit market expansion, with B. Braun Melsungen emphasizing advances in antimicrobial coatings to mitigate these risks.
Market saturation among major urban hospitals presents a barrier, driving companies like Arthrex to focus growth strategies on specialty clinics and ambulatory surgical centers instead.
In 2025, the US knee replacement market by type is led by Total Knee Replacement, capturing the largest share, attributable to its wide indication scope and well-established outcomes. Robotic-assisted and partial knee replacements are also registering growth, driven by technological advancements and rising patient awareness. Revision and gender-specific procedures, while smaller segments, are experiencing growth as aging implants require replacement and customization becomes more prevalent. This competitive landscape highlights the increasing specialization among leading device manufacturers.
US Knee Replacement Market Share by Application, 2025
Osteoarthritis remains the primary application driving knee replacement procedures in the US, accounting for the bulk of surgeries. Rheumatoid arthritis and post-traumatic arthritis represent significant, but smaller, market segments as awareness and early diagnosis improve. There is, however, a growing focus on complex indications such as congenital deformities and bone tumors, expanding the pool of eligible patients. As demographic trends evolve, ongoing education and broader insurance coverage are expected to further shape application shares.
US Knee Replacement Market Revenue (USD Million), 2020-2035
Revenues in the US knee replacement market demonstrated steady growth from 2020 through 2035, reflecting the combined effect of population aging, expanding insurance coverage, and advancements in implant technology. While early years show moderate increases, the 2025-2030 period anticipates accelerated growth due to the uptake of robotic-assisted and minimally invasive procedures, as well as growing demand from the baby boomer cohort. By 2035, market revenues are projected to surpass 13,600 million USD.
US Knee Replacement Market Year-on-Year Growth (%), 2020-2035
The US knee replacement market is expected to experience consistent year-on-year growth, with 2025 and 2030 showing particularly strong performance as new technologies expand accessibility and patient populations. YOY growth is driven by rising procedure volumes, technology upgrades, and expanded clinical indications. However, growth moderates slightly past 2030 as the market matures and competition intensifies.
Market share analysis by region reveals that the South and Midwest regions collectively account for the largest proportion of US knee replacement surgeries, attributed to their higher rates of osteoarthritis and older populations. The Northeast and West show notable presence due to advanced healthcare facilities and higher adoption of new technologies, while other regions are gradually catching up with improved healthcare access and surgeon training.
The US knee replacement market is shaped by prominent players, with Zimmer Biomet, Stryker Corporation, and Johnson & Johnson (DePuy Synthes) collectively holding over half the market. These market leaders continue to innovate across implant design, robotics, and patient-specific approaches. Smaller but significant shares belong to Smith & Nephew, DJO Global, and several emerging players focusing on niche technologies and 3D printing applications.
Hospitals represent the dominant buyer segment for knee replacement products, owing to their large surgical capacities and established supplier relationships. Orthopedic clinics and ambulatory surgical centers are expanding their shares, driven by the shift toward outpatient procedures. Online and retail pharmacies, though smaller in share, are expected to gain prominence as at-home rehabilitation and direct-to-patient models grow.
Study Coverage
Metrics
Details
Years
2020-2035
Base Year
2025
Market Size
10450
Regions
South, Midwest, Northeast, West, Others
Segments
By Type: Total Knee Replacement, Partial Knee Replacement, Revision Knee Replacement, Gender-specific Knee Replacement, Robotic-assisted Knee Replacement, Others; By Application: Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis, Congenital Deformities, Bone Tumors, Others; By Technology: Conventional, Minimally Invasive, Robotic-assisted, 3D Printing, Computer-assisted, Others; By Distribution Channels: Hospitals, Orthopedic Clinics, Ambulatory Surgical Centers, Online Pharmacies, Retail Pharmacies, Others; By Organization Size: Small, Medium, Large
June 2024: Zimmer Biomet announces FDA clearance for its Persona IQ smart knee technology, integrating sensor-driven postoperative monitoring.
July 2024: Stryker expands the MAKO SmartRobotics platform to new ambulatory surgical centers across the Midwest US.
August 2024: Johnson & Johnson launches AI-driven preoperative planning software for knee replacements enhancing surgical accuracy.
September 2024: Smith & Nephew partners with major US healthcare networks to scale digital rehabilitation solutions for knee surgery patients.
October 2024: DJO Global unveils a next-generation modular knee implant line focusing on patient-specific customization.
Frequently Asked Questions
About the Author
Raj K
Senior Market Research Analyst
Raj K is a Senior Market Research Analyst specializing in market research, industry analysis, and business consulting across Healthcare. Raj K brings a commercially grounded perspective to sectors shaped by changing demand, innovation, and competitive dynamics, helping turn complex market trends into clear strategic insights for business decision-makers. With 10+ years of experience across research, analytics, and strategic advisory roles, Raj K has helped organizations translate data into actionable growth strategies.
